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KMID : 0191120010160050623
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Journal of Korean Medical Science
2001 Volume.16 No. 5 p.623 ~ p.629
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Detection of Telomerase Activity in Psoriasis Lesional Skin and Correlaton with Ki-67 Expression and Suppression by Retinoic Acid
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Ho-Sun Jang
Chang-Keun Oh/Ju-Hyun Jo/Yu-Sun Kim*/Kyung-Sool Kwon
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Abstract
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Telomerase activity is usually detected in most tumor tissues but not in normal tissues.
Recently, there is increasing evidence that telomerase activity is associated with cell
proliferation without malignancy, whereas there is little information about telomerase
activity and its relationship with cell proliferation in chronic hyperproliferative skin
diseases. Thus, we studied telomerase activity in skins from 10 patients with psoriasis
and compared telomerase activity with the expression of Ki-67, a proliferation marker,
using immunohistochemical staining. The effect of retinoic acid on the telomerase activity
in HaCaT cells was also evaluated. Telomerase activity was detected in 7 (70%) of 10
lesional skins of psoriasis and none of the nonlesional skin. Telomerase activity in
lesional skin was significantly associated with Ki-67 labelling index. Retinoic acid
treatment on HaCaT cells inhibited telomerase activity, which correlated with inhibition
of cell proliferation by the agent. The results of our study represent another example
that shows telomerase activity correlates with cellular proliferation. Further studies
on the regulation of the telomerase are needed to understand the cellular factors involved
in controlling telomerase activity.
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